Protective Strategies Against Cadmium Chloride-Induced Hepatic Injury: Role of Antioxidants and Experimental Evidence

Abstract

Cadmium chloride (CdCl) is among the most toxic heavy metals in the environment and is extremely harmful even in very small concentrations due to prolonged biological half-life and cumulative characteristics. Something important in cadmium contamination of environment has been rapid industrialization and mining, metal coating (electroplating), production of batteries, pigment synthesis, phosphate fertilizers and use of tobacco as these have been the major ways of introducing cadmium into the air land water, agricultural products, etc. Cadmium exposure leads to deposition mostly in liver and kidney tissues from where it slowly moves out and affects other target organs too. Since the liver has been described as one of the major organs of processing foreign compounds (xenobiotics), neutralizing the foreign body's toxins (detoxification), metabolizing nutrients and managing bodily metabolism, it is most targeted organ in cadmium toxicity. Oxygen free radicals are key in liver cell death (hepatocytelysis) by CdCl via mechanisms such as depletion of antioxidant reserves, generation of intracellular ROS (reactive oxygen species) inflammation DNA damage, peroxidaion in lipids, and apoptosis at the cell level. Experimental studies have been reporting high levels of hepatic enzymes in blood, extensive changes at the tissue level (histopathology), mitochondrial damage and liver fibrosis due to cadmium exposure. These changes are the result of an overall weakening of liver function by the cadmium and may lead ultimately to liver-related illnesses or even liver cancer. This paper reviews the present literature on the use of antioxidants to counteract cadmium-induced damage to the liver. Focus areas included the measurement of oxidative stress, the role of endogenous anti-oxidant defenses, the microscopic appearance of liver tissues before and after cadmium exposure, the molecular basis of hepatic protection, and the newest treatment possibilities of liver injury due to cadmium. The review also outlines the shortcomings of present research, translational barriers, and the future directions which will hopefully lead to new prevention and therapies for liver damage caused by cadmium.

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