STUDY OF KIDNEY FUNCTION MARKERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE (CKD)

Abstract

Chronic Kidney Disease (CKD) is a progressive condition characterized by the gradual loss of kidney function over time. It has emerged as a major public health concern worldwide due to its increasing prevalence, associated morbidity, and mortality. Kidney function markers such as serum creatinine, blood urea, uric acid, estimated glomerular filtration rate (eGFR), and electrolytes play a vital role in the diagnosis, monitoring, and management of CKD patients. This prospective observational study was conducted to evaluate kidney function markers in patients diagnosed with CKD and to assess their clinical significance in disease progression. A total of 100 patients with confirmed CKD were included in the study over a period of twelve months. Blood samples were collected and analyzed using standard biochemical methods. The results showed elevated serum creatinine and blood urea levels in the majority of CKD patients. Reduced eGFR was observed in all patients, with severity varying according to disease stage. Electrolyte abnormalities, particularly hyperkalemia and metabolic acidosis, were common among advanced-stage CKD patients. The findings demonstrated a significant correlation between kidney function markers and the severity of renal impairment. The study concludes that routine assessment of kidney function markers remains essential for early detection, staging, and monitoring of CKD. Timely evaluation of these markers can help improve patient outcomes and reduce disease-related complications.

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