Advances in Wound Healing and Tissue Regeneration: Biomaterials, Regenerative Strategies, and Translational Challenges

Wound healing and tissue regeneration are biological processes that are highly regulated and intricate in nature and are necessary to restore tissue integrity after injury, surgery, or chronic disease. Although there have been considerable improvements in clinical care, impaired wound healing is still a leading health burden in the world, especially in the elderly and those with comorbidities of metabolic, vascular and psychosocial conditions. In the last twenty years, a lot of ground has been covered in the field of wound biology as well as the development of the regenerative approaches, including the use of biomaterials, stem cells, growth factors, nanotechnology, and sophisticated drug delivery systems. This narrative review is a synthesis of modern developments in wound healing and tissue regeneration focusing on the biological processes, new technologies, translational, and systemic factors that predetermine the results in wound healing and tissue regeneration. The review also discusses the importance of digital health, precision medicine, and psychosocial factors on the development of regenerative care. Altogether, the accumulated data have contributed to a change in values of passive wound coverage towards biologically active, patient-centered, and data-driven regenerative therapies.

© 2026 — Authors retain the copyright of this article. This is an open access article distributed under the Creative Commons Attribution License (CC BY 4.0) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.